Advisory Council October 2017 Meeting Presentation: Research Progress



Friday, October 27, 2017

Printer Friendly Version in PDF Format (8 PDF pages)


Research Progress for Alzheimer's Disease and Related Dementias

Richard J. Hodes, M.D.
National Institute on Aging

Program integration toward achieving the 2025 goal of NAPA (from discovery to the clinic)

  • Basic R01's, ADSP, NCRAD
    • Discovery Stage
      • Identify Target
      • Identify Compounds
    • Discovery Stage
      • Establish Activity
      • Select Clinical Candidates
  • Translational Animal center
    • Development Stage
      • Test Safety
  • AD Centers, NACC, ADNI/Biomarkes
    • Development Stage
      • Submit Application for Clinical Trial (IND/CTX/CTA)
      • Human Clinical Trial Phase I
      • Human Clinical Trial Phase II
  • AD Centers, AD Clinical Trials, Consortium
    • Development Stage
      • Submit Registration for Regulatory Approval (NDA/BLA/MAA)
      • Human Clinical Trial Phase III
      • Human Clinical Trial Phase IV

NIA-AD accomplishments FY16-17

  • R01's
    • Who
      • Alzheimer's Disease Genetics Consortium (ADGC) [RENEWED FY16 AND 17]
      • National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) [RENEWED FY16 AND 17]
      • National Cell Repository for Alzheimer's Disease (NCRAD) [RENEWED FY16 AND 17]
    • R01's [NEW PROGRAM]
      • Inflam
      • ApoE
      • Stem cells
      • Synapses
      • Genetics
      • Gau
      • Abeta
    • Who
      • Alzheimer's Disease Sequencing Project (ADSP) [RENEWED FY16 AND 17]
      • Accelerating Medicines Partnership
  • Translational MODEL-AD [NEW PROGRAM]
    • Who
      • NIH Blueprint for Neuroscience Research
  • Biomarkes
    • Who
      • National Alzheimer's Coordinating Center (NACC)
      • Alzheimer's Disease Neuroimaging Initiative (ADNI) [RENEWED FY16 AND 17]
      • Dominantly Inherited Alzheimer Network (DIAN)
    • R01's [NEW PROGRAM]
  • AD Centers [NEW PROGRAM]
    • Who
      • Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease (TRC-PAD) [NEW PROGRAM]
      • Alzheimer's Disease Cooperative Study (ADCS)
      • Alzheimer's Prevention Initiative [RENEWED FY16 AND 17]
      • Dominantly Inherited Alzheimer Network Trials Unit (DIAN TU) [RENEWED FY16 AND 17]
      • Wake Forest University
      • Michigan University
      • BU

Behavioral and Social Approaches to AD/ADRD Research

Research Area Example Topics
Dementia Care
  • Care/nonpharmacologic interventions for persons living with dementia
  • Neighborhood & social factors
Caregiver Research and Interventions
  • Caregiver depression, burden, self-care & social support
  • Economics of caregiving
  • Prevalence, incidence, burden of illness
  • Cross-national comparisons
Behavioral and Social Pathways to ADRD
  • Educational attainment
  • Personality
  • Social engagement
Early Psychological Changes in AD
  • Affective Function
  • Decision-making
  • Social function
  • Interventions on behavioral risk factors
  • Cognitive training
  • Investigate disparities based on race, ethnicity, gender, place (e.g., rural) in dementia care studies & epidemiology

AD and ADRD Research Investments FY14-FY17

Individual Research Grants Clinical Trials
Bar Chart: FY2014 (141); FY2015 (156); FY2016 (319); FY2017 (647). Bar Chart: FY2014 (12); FY2015 (9); FY2016 (23); FY2017 (69).
These figures show grants awarded with NIA funding. Some of the grants are in response to initiatives sponsored by NIH ICs other than NIA (e.g., NINDS, NIBIB, NIEHS, NIDCD).

Interactions among NIA sponsored centers

US Continental map showing the interactions between NACC, GAAIN, IDeA, ADCs, NCRAD, ADGC, NIAGADS.

Opportunities for Small Business -- AD/ADRD specific

  • Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42/R43/R44)
  • Tools for Clinical Care and Management of Alzheimer's Disease (AD) and its Comorbidities (R41/R42/R43/R44)
  • Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R41/R42/R43/R44)

NIA SBIR/STTR Obligations

$ in Millions
Bar Chart: 2013 (27.5); 2014 (32.4); 2015 (34.2); 2016 (49.7); 2017* (68.1).
* Estimate

Save the Dates!

  • Alzheimer's Disease Research Summit (III), March 1-2, 2018, Bethesda, MD
  • ADRD Summit (III), March 14-15, 2019, Bethesda, MD


Other Federal Updates

7 Grants Awarded for FY2017 NINDS Funding Opportunity Announcements

  • 2 Awards for Leveraging Existing Resources (i.e., ADNI/NACC, Parkinson's Disease Biomarker Program) for Research on Lewy Body Dementia (R03)
    • Whole-Methylome Sequencing to Identify Unique Epigenetic Profiles in Lewy Body Dementias (Debby W. Tsuang; Seattle Institute for Biomedical/Clinical research)
    • Applying DNA Methylation for Differential Diagnosis in Lewy Body Dementia (Paula A. Desplats; UCSF)
  • 2 Awards for Frontotemporal Degeneration (FTD) Sequencing Consortium: Discovery, Replication, and Validation (UG3/UH3)
    • Impact of Coding and Non-coding Variation in Progressive Supranuclear Palsy (Giovanni Coppola et al.; UCLA)
    • Whole Genome Sequencing Consortium on Frontotemporal Dementia with Underlying TDP-43 Pathology (Rosa Rademakers; Mayo Clinic Jacksonville)
  • 3 Awards for Detecting Cognitive Impairment, Including Dementia, in Primary Care and Other Everyday Clinical Settings for the General Public and in Health Disparities Populations (UG3/UH3)
    • Mycog -- Rapid Detection of Cognitive Impairment in Everyday Clinical Settings (Richard Gershon et al.; Northwestern)
    • The UCSF Brain Health Assessment for the Detection of Cognitive Impairment Among Diverse Populations in Primary Care (Katherine L. Possin; UCSF)
    • 5-Cog Battery to Improve Detection of Cognitive Impairment and Dementia (Joe Verghese; Albert Einstein College of Medicine)

VA Research Update

  • U.S. Department of Veterans Affairs (VA) partnering with National Institute on Aging(NIA) to foster new networks & leverage resources, funding in Alzheimer's Disease (AD) and Alzheimer's Disease Related Dementias (ADRD).
    • Request for information (RFI) issued last year:
    • Strategic Partnership for Advancing Research and Knowledge (SPARK)-Dementia Research, now forming workgroups around:
      1. Basic mechanisms and pathogenesis of AD and ADRD;
      2. Genetic and population studies;
      3. Diagnosis and disease monitoring;
      4. Translational and clinical research;
      5. Care and caregiver research.

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