Advisory Council April 2017 Meeting Presentation: Research Budget and FOAs



Monday, April 17, 2017

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Alzheimer's and Related Dementias Research: Budget and FOAs

Richard J. Hodes, M.D.
National Institute on Aging

Budget Status

  • FY16 - $32B increase for NIH, including $1.6B for NIA (including $350M for AD/ADRD)
  • FY17 Draft Appropriations bills included additional NIH funds for AD ($350-400M)
  • CR running through April 28th
  • President's Budget for FY18 -- $5.8B decrease for NIH, no specifics for ICs


CR Initial Pay Lines

CSR-reviewed Research Applications
  General Pay line, <$500k General Pay line, =>$500k ADRD pay line, <$500k ADRD pay line, =>$500k
All applications except N.I. or E.S.I. R01s 11% 8% 18% 15%
N.I. R01s 14% 11% 21% 18%
E.S.I. R01s 16% 13% 23% 20%
* Investigator initiated projects only. Pay lines for applications in response to PARs will be set in the near future


NIA-reviewed Applications
  General Pay line ADRD pay line
Program projects (PO1) 28 31
Other NIA-reviewed research 22 30
* Investigator initiated projects only. Pay lines for applications in response to PARs will be set in the near future


Training-related Applications
  General pay line ADRD pay line
Training grant (T32, T35) 19 27
Career awards 16 27
Fellowships 26 33

Alzheimer's FOAs

  • Resource Leverage- 6 active
  • Caregiving and Clinical Care- 4 active
  • Translation- 3 active
  • Basic research- 9 active
  • Training- 2 active


New NINDS Funding Opportunity Announcement in partnership with NIA:

  • Detecting Cognitive Impairment, Including Dementia, in Primary Care and Other Everyday Clinical Settings for the General Public and in Health Disparities Populations (UG3/UH3) RFA-NS-17-012
    • The purpose is to address the unmet need to detect cognitive impairment / dementia when a patient, a relative, or a caregiver voices a concern. Proposed clinical paradigms should utilize easy-to-use tools that are standardized and take less than 5 minutes to administer in a primary care setting.
    • Applications are due May 9, 2017


MarkVCID: National Consortium to develop clinical trial-ready VCID biomarkers

  • Established through FY 2016 FOA -- 7 project sites across the US & 1 coordinating center
  • Consortium Kickoff meeting was Feb 20-21, 2017


Research Planning and Initiatives

AHRQ-National Academies Study

Two-part assessment of the science of prevention strategies for AD-type dementia, amnestic MCI, and age-related cognitive decline- the process will be complete in June 2017

Save the Dates!

  • AD Care and Services Research Summit, October 16-17, 2017, Bethesda, MD
  • Alzheimer's Disease Research Summit (III), March 1-2, 2018, Bethesda, MD


Most Recent AD/ADRD FOAs

Resource Leverage (6)

  • Leveraging Existing Cohort Studies to Clarify Risk and Protective Factors for Alzheimer's disease and related dementias
  • Revision Requests for Active Alzheimer's Disease Research Centers
  • Revision Requests for Active Alzheimer's Disease Core Centers
  • NIA Research Centers Coordinating Network
  • NIA Late Onset of Alzheimer's Disease (LOAD) Family-Based Study
  • NIA Genetics of Alzheimer's Disease Data Storage Site


Caregiving and Clinical Care (4)

  • Development of Socially-Assistive Robots to Engage Persons with ADRD and their Caregivers (2 mechanisms)
  • Improving Quality of Care and Quality of Life for Persons with Alzheimer's Disease and Related Dementia at the End of Life (2 mechanisms)
  • Tools for Clinical Care and Management of Alzheimer's disease and its Comorbidities (2 mechanisms)
  • Clarifying the Relationship between Delirium and Alzheimer's disease and related dementias (2 mechanisms)


Translation (3)

  • Translational Bioinformatics Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimer's Disease
  • Advancing Research on Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) (2 mechanisms)
  • Translational Research on Aging: Small Business Innovation Awards (2 mechanisms)


Basic Research (9)

  • Integrative Research to Understand the Impact of Sex Differences on the Molecular Determinants of AD Risk and Responsiveness to Treatment
  • Mechanisms and Interactions Among Neurodegenerative Diseases
  • Comparative Biology of Neurodegeneration
  • Dynamic Interactions between Systemic or Non-Neuronal Systems and the Brain in Aging and in Alzheimer's Disease
  • Basic and Translational Research on Decision Making in Aging (2 mechanisms)
  • Selective Cell and Network Vulnerability in Aging and Alzheimer's Disease
  • Role of Age-Associated Metabolic Changes in Alzheimer's Disease
  • Limited Competition: Additional Sequencing for the Alzheimer's Disease Sequencing Project
  • Phenotypic and Functional Characterization of ApoE2 to Inform Translation Strategies for Aging-Related Conditions (2 mechanisms)


Training (2)

  • Revision Awards to Institutional Training Programs to Advance Translational Research for Alzheimer's Disease and AD Related Dementias
  • Research Career Enhancement Award to Advance Therapy Development for AD and Related Dementias and Alzheimer's Disease

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