Advisory Council July 2020 Meeting Presentation: ADRD FY 2022 Bypass Budget

07/20/2020

ADVISORY COUNCIL ON ALZHEIMER'S RESEARCH, CARE, AND SERVICES

Monday, July 20, 2020

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Alzheimer’s Disease and Related Dementias Research Update -- FY 2022 Bypass Budget

Richard J. Hodes, M.D.
Director, National Institute on Aging

Bypass Budget Language

SEC. 230. Hereafter, for each fiscal year through fiscal year 2025, the Director of the National Institutes of Health shall prepare and submit directly to the President for review and transmittal to Congress, after reasonable opportunity for comment, but without change, by the Secretary of Health and Human Services and the Advisory Council on Alzheimer’s Research, Care, and Services, an annual budget estimate (including an estimate of the number and type of personnel needs for the Institutes) for the initiatives of the National Institutes of Health pursuant to the National Alzheimer’s Plan, as required under section 2(d)(2) of Public Law 111–375.

Combined External and Internal Input -- FY22 AD/ADRD Bypass Budget

  1. Input at 2012-2019 meetings:
    • Academic research community
    • Industry
    • Non-governmental organizations
  2. Development of comprehensive milestones (NIH staff) -- based on summit and other input
  3. Trans-NIH (including NINDS) staff discussion; milestones edited to ensure comprehensive inclusion of priorities for FY22
  4. NIH staff “price” the milestones
  5. Final budget estimate for FY22

Using CADRO as a Framework

  • The eight CADRO (Common Alzheimer’s Disease Research Ontology) categories provide the overarching framework for the FY22 AD Bypass Budget and narrative.
  • CADRO provides the framework for IADRP (the International Alzheimer’s Disease Research Portfolio) and will allow tracking of implementation in the budget areas in future years.

Professional Judgment Budget FY 2022, Projected Costs and Additional Resources Needed

Fiscal Year 2022 Professional Judgment Budget: Alzheimer's Disease and Related Dementia
Baseline Estimate, President's Budget, Fiscal Year 2021 Alzheimer's Disease, including Alzheimer's Disease-Related Dementias (AD/ADRD)[1] $2,564,000,000
Professional Judgment Budget FY 2022, Projected Costs, and Additional Resources Needed
Areas of Research Amount
Molecular Pathogenesis and Pathophysiology of Alzheimer's Disease $51,500,000
Diagnosis, Assessment, and Disease Monitoring $26,000,000
Translational Research and Clinical Interventions $131,100,000
Epidemiology $56,000,000
Care and Caregiver Support $39,500,000
Research Resources $82,700,000
Alzheimer's Disease-Related Dementias $43,305,222
Staffing Needs and Administrative Support $3,993,000
Total Costs for New AD/ADRD Research $434,214,444
Less: Funding from Prior Appropriations that is available for New AD/ADRD Research ($145,000,000)
ADDITIONAL FY 2022 Resources Needed for New AD/ADRD Research[2] $289,214,444

Distribution of FY 2022 Projected Costs Across Research Areas

Circle chart: Staff Needs, Support, and Misc ($3,993,000), Molecular Pathogenesis and Pathophysiology of Alzheimer's Disease ($51,500,000), Diagnosis, Assessment and Disease Monitoring ($26,000,000), Translational Research and Clinical Interventions ($131,100,000), Epidemiology ($56,000,000), Care and Caregiver Support ($39,500,000), Research Resources ($82,700,000), Alzheimer's Related Dementias ($43,421,444)

Total Projected Costs: $434,214,444*

Additional Resources Needed for New Research: $289,214,444

* In FY 2022, the projected costs of resources needed for new research to enhance investigator-initiated research grants and initiatives to meet the 2025 treatment/prevention goal is $434 million. This estimate will be reduced by $145 million in funding that is projected to become available after completion of previously funded AD/ADRD research initiatives. As a result, the additional resources needed for new research in the FY 2022 budget is $289 million.

Total Resource Needs, FY 2022

Factor Amount
FY 2021 President's Budget Request for AD/ADRD Research (Baseline estimate) $2,564,000,000
Difference between the FY 2021 President's Budget Request and FY 2020 Appropriation for AD/ADRD Research[3] $254,000,000
ADDITIONAL FY 2022 Resources Needed for New AD/ADRD Research $289,214,444
TOTAL FY 2022 Resources Needed for AD/ADRD Research $3,107,214,444

AD/ADRD Progress Report -- An important part of the ADBB

The AD/ADRD Bypass Budget narrative includes many examples of recent science advances across multiple research topics – basic to clinical, care/caregiving, etc

https://www.nia.nih.gov/about/bypass-budget-proposal-archive

Implementation Tracking

NIA -- The Leader in Aging Research

 


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