Advisory Council January 2020 Meeting Presentation: Federal Research Update

01/27/2020

ADVISORY COUNCIL ON ALZHEIMER'S RESEARCH, CARE, AND SERVICES

Monday, January 27, 2020

Printer Friendly Version in PDF Format (8 PDF pages)

 

Alzheimer's Disease and Related Dementias Research Update

Richard J. Hodes, M.D.
Director, NIA

FY 2020 Budget- Funding Increases Across the Board

  • $41.7 Billion for the NIH
    • $500M for All of Us
    • $500M for BRAIN
    • $60M for Down Syndrome
    • $350M increase for AD/ADRD ($2.8B total)
    • $3.54B for the NIA
      • $110.3M increase for non-targeted NIA research
      • All divisions will benefit
        • DBSR
        • DGCG
        • DAB
        • DN

NIA AD/ADRD Appropriations

  • 2011
    • National Alzheimer's Project Act (NAPA)
  • 2012
    • $50 M* redirected within NIH budget
  • 2013
    • $40 M* redirected within NIH budget
  • 2014
    • $100 M additional approp
  • 2015
    • $25 M additional approp
  • 2016
    • $350 M additional approp
  • 2017
    • $400 M additional approp
  • 2018
    • $414 M additional approp
  • 2019
    • $414 M additional approp
  • 2020
    • $350M in additional appropriations as of 12/20/19

*one-year money
Years displayed are Fiscal Years

NIH Funding for AD/ADRD Research -- in millions
From NIH's Research, Condition, and Disease Categories (RCDC) System

Research/Disease Areas
(Dollars in millions and rounded)
FY 2015 FY 2016 FY 2017 FY 2018 Difference --
FY18 to FY15
AD/ADRD $631 $986 $1,423 $1,911 3.0-fold increase
Alzheimer's Disease $589 $929 $1,361 $1,789 3.0-fold increase
Alzheimer's Disease Related Dementias[1] $120 $175 $249 $387 3.2-fold increase
   Lewy Body Dementia $15 $22 $31 $38 2.5-fold increase
   Frontotemporal Dementia $36 $65 $91 $94 2.6-fold increase
   Vascular Cognitive Impairment/Dementia $72 $89 $130 $259 3.6-fold increase
  1. The ADRD row reflects the sum of the three existing RCDC categories: Frontotemporal Dementia, Lewy Body Dementia, and Vascular Cognitive Impairment/Dementia--where duplicates are removed.

https://report.nih.gov/categorical_spending.aspx

NIA AD Translational Research Program: Diversifying the Therapeutic Pipeline

Multiple funding mechanisms support each step of the drug development process
Pipeline diagram.

 

Multiple funding mechanisms support each step of the drug development process
Same Pipeline diagram, with the addition of additional mission information under TREAT-AD Centers Consortium.
https://www.nia.nih.gov/news/nih-funded-translational-research-centers-speed-diversify-alzheimers-drug-discovery

Active NIA AD/ADRD and Related Intervention and Prevention Trials (~230)

  • 37 Early-stage Clinical Drug Development (Phase I and Phase II Clinical Trials)
    • Amyloid (10)
    • Receptors (2)
    • Neuroprotection (6)
    • Metabolism and Bioenergetics (2)
    • Vasculature (3)
    • Growth Factors and Hormones (2)
    • Multi-target (1)
    • Inflammation (2)
    • Oxidative Stress (2)
    • Other (7)
  • 9 Late-stage Clinical Drug Development (Phase II/III and Phase III Clinical Trials)
    • Amyloid (6)
    • Neuroprotection (2)
    • Vasculature (1)
  • 108 Non-Pharma-cological Interventions
    • Exercise (23)
    • Diet (8)
    • Cognitive Training (23)
    • Assistive Tech. (13)
    • Sleep (4)
    • Combination Therapy (11)
    • Other (26)
  • 8 Clinical Therapy Development for the Neuro-psychiatric Symptoms of AD/ADRD
    • Pharmacological (5)
    • Non-Pharmacological (3)
  • 67 Care and Caregiver Interventions
    • Improving Care for PWD (26)
    • Improving care provided by family or informal caregiver (41)

https://www.nia.nih.gov/research/ongoing-AD-trials

Behavioral and Social Research on Alzheimer's Disease and Related Dementias

Flower-shaped diagram showing 7 circles around a center Research Resources circle. The outer circles are Prevention, Caregiver Research, Dementia Care, Disparities, Cognitive + Dementia Epidemiology, Behavioral + Social Pathways, Early Psychological Changes.

 

Same Flower-shaped diagram, with Cognitive + Dementia Epidemiology outer petal circled.

AD/ADRD Epidemiology Initiatives at NIA