ADVISORY COUNCIL ON ALZHEIMER'S RESEARCH, CARE, AND SERVICES
Monday, January 27, 2020
Printer Friendly Version in PDF Format (8 PDF pages)
Alzheimer's Disease and Related Dementias Research Update
Richard J. Hodes, M.D.
Director, NIA
FY 2020 Budget- Funding Increases Across the Board
- $41.7 Billion for the NIH
- $500M for All of Us
- $500M for BRAIN
- $60M for Down Syndrome
- $350M increase for AD/ADRD ($2.8B total)
- $3.54B for the NIA
- $110.3M increase for non-targeted NIA research
- All divisions will benefit
- DBSR
- DGCG
- DAB
- DN
NIA AD/ADRD Appropriations
- 2011
- National Alzheimer's Project Act (NAPA)
- 2012
- $50 M* redirected within NIH budget
- 2013
- $40 M* redirected within NIH budget
- 2014
- $100 M additional approp
- 2015
- $25 M additional approp
- 2016
- $350 M additional approp
- 2017
- $400 M additional approp
- 2018
- $414 M additional approp
- 2019
- $414 M additional approp
- 2020
- $350M in additional appropriations as of 12/20/19
*one-year money
Years displayed are Fiscal Years
NIH Funding for AD/ADRD Research -- in millions
From NIH's Research, Condition, and Disease Categories (RCDC) System
| Research/Disease Areas (Dollars in millions and rounded) |
FY 2015 | FY 2016 | FY 2017 | FY 2018 | Difference -- FY18 to FY15 |
|---|---|---|---|---|---|
| AD/ADRD | $631 | $986 | $1,423 | $1,911 | 3.0-fold increase |
| Alzheimer's Disease | $589 | $929 | $1,361 | $1,789 | 3.0-fold increase |
| Alzheimer's Disease Related Dementias[1] | $120 | $175 | $249 | $387 | 3.2-fold increase |
| Lewy Body Dementia | $15 | $22 | $31 | $38 | 2.5-fold increase |
| Frontotemporal Dementia | $36 | $65 | $91 | $94 | 2.6-fold increase |
| Vascular Cognitive Impairment/Dementia | $72 | $89 | $130 | $259 | 3.6-fold increase |
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NIA AD Translational Research Program: Diversifying the Therapeutic Pipeline
| Multiple funding mechanisms support each step of the drug development process | |||
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| Multiple funding mechanisms support each step of the drug development process | |||
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| https://www.nia.nih.gov/news/nih-funded-translational-research-centers-speed-diversify-alzheimers-drug-discovery | |||
Active NIA AD/ADRD and Related Intervention and Prevention Trials (~230)
- 37 Early-stage Clinical Drug Development (Phase I and Phase II Clinical Trials)
- Amyloid (10)
- Receptors (2)
- Neuroprotection (6)
- Metabolism and Bioenergetics (2)
- Vasculature (3)
- Growth Factors and Hormones (2)
- Multi-target (1)
- Inflammation (2)
- Oxidative Stress (2)
- Other (7)
- 9 Late-stage Clinical Drug Development (Phase II/III and Phase III Clinical Trials)
- Amyloid (6)
- Neuroprotection (2)
- Vasculature (1)
- 108 Non-Pharma-cological Interventions
- Exercise (23)
- Diet (8)
- Cognitive Training (23)
- Assistive Tech. (13)
- Sleep (4)
- Combination Therapy (11)
- Other (26)
- 8 Clinical Therapy Development for the Neuro-psychiatric Symptoms of AD/ADRD
- Pharmacological (5)
- Non-Pharmacological (3)
- 67 Care and Caregiver Interventions
- Improving Care for PWD (26)
- Improving care provided by family or informal caregiver (41)
https://www.nia.nih.gov/research/ongoing-AD-trials
Behavioral and Social Research on Alzheimer's Disease and Related Dementias
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AD/ADRD Epidemiology Initiatives at NIA
- Funding Opportunity Announcements
- Major Opportunities for Research in Epidemiology of AD/ADRD and Cognitive Resilience
- Active until November 13, 2021
- Centers on the Demography and Economics of AD/ADRD
- Recently closed- earliest project start date April 2020
- High-Priority Behavioral and Social Research Networks in AD/ADRD
- Two projects recently awarded
HRS Family Studies Around the World
https://hrs.isr.umich.edu/data-products The Healthy Cognitive Aging Project (HCAP) Dementia Assessment in HRS-Family Studies
- The now-global consortium of studies (HRS-sister studies) collecting rich cognitive data using the Harmonized Cognitive Assessment Protocol
- https://hrs.isr.umich.edu/data-products/cognition-data
Dementia Care, Caregiving, & Services Summit
- Save the Date
- March 24-25, 2020
- Natcher Conference Center, Bethesda, MD
- Registration open now!
- https://www.nia.nih.gov/2020-dementia-care-summit
NIH's 2nd Inclusion Across the Lifespan Workshop
- Save the Date
- September 2-3, 2020
- Natcher Conference Center NIH Main Campus, Bethesda, MD
- A Request for Information (RFI) open until February 15, 2020
- https://grants.nih.gov/grants/guide/notice-files/NOT-OD-20-044.html
Return to
National Alzheimer's Project Act Home Page
Advisory Council on Alzheimer's Research, Care, and Services Page
Advisory Council on Alzheimer's Research, Care, and Services Meetings Page
- Major Opportunities for Research in Epidemiology of AD/ADRD and Cognitive Resilience