Friday, April 29, 2016
Terminology Heterogeneity
Ronald C. Petersen, PhD, MD
Mayo Clinic
Dementia
Multiple Terminologies
- AD spectrum
- ADRD
- DSM-5
- Dementia
- MCI
- Prodromal
Old Conception of Alzheimer’s Disease
Cognitive Continuum
Alzheimer’s Disease Spectrum
Alzheimer’s Disease Spectrum
Evolution of MCI Criteria Including Prodromal AD
![Timelines: 1979 - 2013, 2007 - 2013.](/sites/default/files/private/images-site-pages/201481/Mtg20-Slidefig1f.jpg) |
Petersen, Continuum, in press |
Diagram
- Clinical Spectrum CN - MCI - Dementia [Clinical]
- Aß [Pathology]
- TAU [Pathology]
- Other [Pathology]
- Vascular Disease [Pathology]
- Alpha Synuclein [Pathology]
- TDP-43 [Pathology]
Diagram
- Clinical Spectrum CN - MCI - Dementia [Clinical]
- Aß [Pathology]
- TAU [Pathology]
- Other [Pathology]
- Vascular Disease [Pathology]
- Alpha Synuclein [Pathology]
- TDP-43 [Pathology]
Introduction to the Recommendations from the National Institute onAging-Alzheimer’s Association Workgroups on Diagnostic Guidelinesfor Alzheimer’s Disease
Clifford R. Jack, Jr, Marilyn S. Albert, David S. Knopman,Guy M. McKhann, Reisa A. Sperling, Maria C. Carrillo,Bill Thies, Creighton H. Phelps
Alz and Dementia, 2011
DSM 5
Mild Neurocognitive Disorder (MCI) |
Major Neurocognitive Disorder (Dementia) |
Cognition
Independence |
- Cognitive decline
- Single cognitive domain impaired (usually)
- Preservation of independence
|
- Cognitive decline
- Significant cognitive impairment in one or more often multiple cognitive domains
- Loss of independence
|
Mild Cognitive Impairment
![Flow chart.](/sites/default/files/private/images-site-pages/201481/Mtg20-Slidefig1i.jpg) |
Petersen et al., J Int Med, 2013 |
Alzheimer’s Disease Spectrum