Understanding the High Prevalence of Low-Prevalence Chronic Disease Combinations: Databases and Methods for Research. Appendix A – Literature Search Methodology

09/20/2013

The literature search methodology outlines the MEDLINE search strategy that was used to conduct the literature review of the peer-reviewed and grey literature related to prevalence of MCC, disease combinations, diagnosis coding, and databases and analytic techniques that have been used to conduct chronic disease research. The number of papers that were identified with each search term and combination are presented.

Search Strategy

MEDLINE

  • Date – Last 10 Years (as of January 1, 2013)
  • Language – English
  • Limits – Human
  • Limits – Abstract Available
  • Search Field Tags – All fields

Key Terms

Search # Key Terms Number of Articles
#1 Chronic Disease/classification/epidemiology/economics 2425
#2 Multiple Chronic Conditions 127
#3 Multimorbidity 207
#4 Comorbidity 42895
#5 Disease Combinations 11
#6 Aging Chronic Disease 3236
#7 Health Expenditures 4888
#8 Economics 96447
#9 Healthcare Utilization 30769
#10 Healthcare Costs 27841
#11 Cost of Illness 11424
#12 United States 611178
#13 Clinical Coding 5252
#14 Medical Informatics 109606
#15 Multiple Chronic Conditions Data Sets 15
#16 # 1 AND #7 119
#17 # 1 AND #8 678
#18 # 1 AND #9 243
#19 # 1 AND #10 257
#20 # 1 AND #11 183
#21 #16 OR #17 OR #18 OR #19 OR #20 799
#22 # 21 AND #12 442
#23 # 4 AND #7 197
#24 # 4 AND #8 2611
#25 # 4 AND #9 1211
#26 # 4 AND #10 1032
#27 # 4 AND # 11 675
#28 # 22 OR #23 OR #24 OR #25 OR #26 3529
#29 #27 AND #12 1904
#31 # 6 AND #7 38
#32 # 6 AND #8 186
#33 # 6 AND #9 69
#34 # 6 AND #10 98
#35 # 6 AND #11 58
#36 #31 OR #32 OR #33 OR #34 OR #35 261
#37 # 13 AND #1 8
#38 # 13 AND #2 2
#39 # 13 AND #3 1
#40 # 13 AND #4 73
#50 # 13 AND #5 0
#51 # 37 OR # 38 OR #39 OR #40 OR #41 80
#52 # 14 AND #1 124
#53 # 14 AND #2 6
#54 # 14 AND #3 8
#55 # 14 AND #4 1217
#56 # 14 AND #5 2
#57 #52 OR #53 OR #54 OR #55 OR #56 1328
#58 #57 AND #12 545
#59 #2 OR #3 OR #5 OR #15 OR #22 OR #28 OR #36 OR #51 OR #58 3323

Article Selection

  • A title review of 3,323 articles.
    • 3,201 articles eliminated due to one of following:
      • Single disease focus
      • Clinical interventions, therapies, and prevention practices
      • Quality improvement practices and interventions
      • Unrelated to topic
  • An abstract review of 122 articles.
    • 53 articles eliminated due to one of the following:
      • Single disease focus
      • Clinical interventions, therapies, and prevention practices
      • Quality improvement practices and interventions
      • Unrelated to topic
  • 69 relevant articles were identified during the abstract review for potential incorporation into the white paper. Additional relevant articles, not identified by the search methodology, were identified by the co-project officers, TAG and Key Informants.

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