Public Comment Index for the National Alzheimer's Project Act . 2018 Comments



N. Satyadev  |  02-23-2018

I want to inform you on some updates from The Youth Movement Against Alzheimer's.

Our low-cost caregiver respite program has officially launched, and details of the program can be found at Within just 9 days of advertising our program, we have received application from over 30 students.

Our efforts to pass a California Care Corps Act have received a bill number: AB 2101.

I promise you, my generation cares deeply about this issue, and I hope you will continue to explore inter-generational to the care and prevention of this disease.


S. Dergantz  |  02-08-2018

More than 5 million Americans currently live with Alzheimer’s, and that number could triple by 2050.

I’m writing you today to ask you to cosponsor the CHANGE Act. The CHANGE Act promotes timely detection and diagnosis of Alzheimer’s, promotes innovative approaches to supporting family care partners and removes regulatory barriers to disease-modifying treatments. This bipartisan bill has the power to fight Alzheimer’s on multiple fronts, and I urge you to cosponsor the bill.

Please do the right thing and cosponsor the CHANGE Act to help us stop Alzheimer’s!



T. Young  |  01-26-2018

Thank you for the opportunity to address the Advisory Council. I find the work you do to be extremely important. As a researcher and caregiver for someone with dementia I have a comment regarding the research updates. I have noticed that CMS, the VA, and ACL show a wide range of projects undertaken at the various agencies. However the NIH ony presents research efforts undertaken by the NIA. I believe I've seen a few other institutes mentioned and one presentation by the NINDS. I would apriciate hearing what is happening at other agencies, like the NINR, NHLBI, and NIGMS. While I acknowledge that the NIA and NINDS oversees the majority of Alzheimer's research I would like to see more updates that include the whole NIH and to see how the institute as a whole is addressing the national plan.


R. Louie  |  01-23-2018

This is probably too late, and may not be appropriate for a NAPA comment, but I'm submitting it for either the NAPA meeting this week or next quarter.


Matter of Fact

Ron Louie, MD

Her face was matter of fact when she heard the prounouncement. The neuropsychologist was her colleague; he remained professional, but slipped in some sympathy with the data, which I could not appreciate.

She didn't display a mask of depression, or Parkinson disease. Her face remained pliable, not pleased, but neither terribly pained, no exhibition of perplexity, or petulance, or surprise, a pensive look, retaining its complex grace, a quiet reserve, a solemn alertness, the beauty of humane consciousness, with no further expectations.

In her own practice, she had encountered Early Alzheimer first hand: that wonderful younger woman, whose baby she had delivered, working in accounting until the numbers became exotic, then alien; she had told me about that patient, with shock, sadness, and resignation.

But I didn't understand this. I wouldn't. It was the guy, his tests, the setting. At home, I made her try to draw a clock, count backward, recite words, and copy intersecting rectangles. She tried, this good doctor who had always bested me in calculus, organic chemistry and marriage. She wasn't angry.

So how could I be mad? She was setting the example, as she had done her whole life, her whole career, without pessimism or regret, or fanfare, just ready to go on, even though her words and steps might mutate, unpredictably, ever aware of the possible endpoints, with each of us now grappling this present moment, trying to recognize its identity.

Dedicated to IRJ, MD; suggested by Meryl Comer

Neurology® 2018;90:139.


E. Neebe  |  01-20-2018

I would like to respectfully ask you to consider the impact of violent Alzehimer's patients in society at large.

As the population ages, this is likely to become a significant problem. Innocent neighbors of these people need to be protected.

My mother was attacked by such a patient on her own front porch on September 13, and she died of her injuries on September 14 without ever regaining consciousness.

The perpetrator lived across the street from my mother.

The perpetrator had a previous history of attacking neighbors, and a long string of complaints, but his wife kept checking him out of institutions and bringing him home.

The police and social services "did what they could," which was not much. Social services was actually instrumental in returning him to his home a month or so before he attacked and killed my mother.

His wife is a hoarder, and the conditions in their home are unlivable.

This family is not short of money.

My mother is dead...a homicide victim...but the state will not prosecute because this man has a diagnosis of Alzheimer's. His family released his medical record to protect him from prosecution.

Things have improved for the perpetrator...his family has finally put him in a private memory support unit (did they have to lie about his violence to get him in?), and his wife has gotten rid of an abusive husband whom she was likely abusing herself.

My mother is dead. My family is devastated.

As you do your work, please pay attention to the harm a violent Alzheimer's patient can do to innocent bystanders.


F. Li  |  01-19-2018

On behalf of the Physicians Committee for Responsible Medicine, I would like to thank all the council members and support staff of the NAPA Advisory Council for your tireless efforts towards finding solutions for Alzheimer's disease. As a nonprofit organization based in Washington, DC working to advance medical research, we support the mission and goals of the National Alzheimer's Plan and hope to provide useful insights towards finding a disease-modifying treatment for Alzheimer's disease and related dementia (AD/ADRD) by 2025.

As the research subcommittee discusses "The Journey from Targets to Treatments", we urge the Council to consider three research paradigm shifts that may help us develop a disease modifying treatment for AD/ADRD:

  1. Replacing animal models with human-relevant models: Even though animals do not develop Alzheimer's disease like humans do, scientists continue to rely on using genetically-engineered animal models for disease mechanistic studies and drug development. Even when animals are manipulated to develop the disease, it is clear that they have species-specific physiological differences that can lead scientists down the wrong therapeutic development path or impede the clinical translation of drug candidates. For instance, Parrott et al.[1] reported in Neurobiology of Aging that a Mediterranean diet worsened cognitive function in a mouse model of Alzheimer's disease even though the diet has been repeatedly demonstrated to be beneficial to humans for Alzheimer's disease. The long history of recurrent drug trial failures in humans despite successes in the animal models also strongly supports that these models are not reliable and we need to push Alzheimer's drug discovery pipelines to replace animal models with human-relevant research models and methods like human stem cell derived minibrains, patient tissues, and predictive toxicology frameworks such as adverse outcome pathways. Today, with -- omic technologies and CRISPR/CAS9 gene-editing techniques, human models have the potential to be more informative than ever before. Supporting research applying these methods to human models and developing new methods to use human-relevant models for ADRD research may help us to overcome translational barriers in ADRD research. Some investment is currently being made into 21st-century models and methods using human cells and tissues. However, we need much more investment in these areas quickly.
  2. Focusing on modifiable lifestyle risk factors as targets instead of pathological hallmarks: While amyloid and tau are well-recognized pathological hallmarks of Alzheimer's disease, they may only be observable abnormalities that result from the disease process rather than drivers of the disease process. Just as we should not focus on pathological features like cotton-wool spots as treatment targets for diabetes, we should not disproportionately invest in targeting amyloid and tau for Alzheimer's disease. The fact that there is no cognitive benefit in patients despite evidence confirming the reduction of amyloid load with candidate drugs in clinical trials suggests that amyloid and tau may not be driving the disease. Moreover, they are not very sensitive or specific biomarkers for the disease. We should consider developing treatments to modify lifestyle risk factors that may drive the disease, such as saturated fat, cholesterol, and inflammatory biomarkers. If we can learn a lesson from disease-modifying treatments in other chronic diseases, it is that treating these lifestyle risk factors is effective for modifying diseases like heart disease and diabetes.
  3. Evaluating lifestyle interventions as first-line, disease-modifying treatments: Alzheimer's disease, like other chronic disease, may be highly driven by lifestyle factors like poor diet and physical inactivity. Hence, the disease could be prevented and possibly reversed by changing lifestyle habits, as demonstrated by the successes of lifestyle modification trials like the FINGER trial. It is important to realize that lifestyle interventions like a change in dietary pattern may not only be preventative but also therapeutic, as we have found for many other chronic diseases. The concept of using "food as medicine" was proposed by Hippocrates, the Father of Medicine, and it is about time that the science catches up to his insight. We need public funding to support research in this area, as the private sector does not have a financial incentive to invest in research into these types of treatments. Lifestyle interventions offer the greatest potential to curb the course and financial burden of this disease.


As it was once said, "The definition of insanity is doing something over and over again and expecting a different result." The many failed trials in the past decades suggest that we ought to do something different. Given the unreliability of the animal models and the poor candidacy of amyloid and tau as drug targets, we recommend the Council to focus on supporting research for human-relevant models, lifestyle risk factors as targets, and non-pharmacological lifestyle interventions for the therapeutic development pipeline. These conceptual paradigm shifts may be our only promising hope to develop effective interventions to prevent or reverse AD/ADRD in our nation by 2025.

Thank you for your attention to these comments. I can be reached using the information below to answer any questions or discuss these comments further.


  1. Parrott MD, et al. Whole-food diet worsened cognitive dysfunction in an Alzheimer's disease mouse model. Neurobiol Aging. 2015 Jan;36(1):90-9.


M. Sharp  |  01-19-2018

Thank you once again for this opportunity to provide input from the perspective of a "related dementia". I am the Program Manager for The Association for Frontotemporal Degeneration.

I look forward to the presentations this afternoon and hope my comments are not preemptively redundant or too off target but I would like to offer some input on drug development in FTD and let everyone know about a new funding opportunity from AFTD.

Designing studies and clinical trials in FTD is a tremendous challenge for many reasons. For starters, as a rare disease, it is hard to recruit enough participants to sample and produce statistically significant results. Also there are multiple pathologies in FTD that underlay a confusing mix of clinical presentations and symptoms. This makes it exceedingly difficult to identify clinically meaningful end-points by which to measure the effectiveness of a treatment. And that is just scratching the surfacing. Basically, the closer you look at designing trials and studies in FTD the more complexity you see. Because of the many and varied challenges AFTD's approach to maximize the success of our research efforts has been to work collaboratively with other organizations and combine resources to find creative solutions. For example The Frontotemporal Study Group is an AFTD program that brings together stakeholders from industry, academia, NIH, FDA and independent foundations who share a common interest in accelerating the development of effective treatments for FTD and related disorders. And last spring AFTD launched the FTD Disorders Registry with our partner the Bluefield Project. There are now over a thousand people registered and ready to inform pharmaceutical companies, academic researchers, regulatory and policy groups about patient-focused trial design and cultivate a collaborative environment for drug development.

Finally, I would like to let everyone know that AFTD has recently announced a new pilot grant to support the development of nonpharmacological therapies for FTD. We have recently released a request for proposals for nonpharmacological interventions and tools with the potential to have a positive impact on the quality of life for persons diagnosed and their families. It is a one year grant up to $60,000 and is open to US and international investigators. There is more information on our website and anyone who is interested is welcome to ask me for more details.


M. Brown-Ekeogu  |  01-19-2018

I'm 51 years old and taking care of my husband who was diagnosed with Frontal Temporal Degeneration in the spring 2017. He is slowly degressing and because we had just purchased a home a few years before his diagnosis I'm the primary caretaker and provider for the family. I live in the state of GA where I was advised we don't have any program in place or funding in place for the spouse to stay at home and care for their loved one. I have exhausted every dime I have in paying someone to be home with him most of the time I'm at work. We NEED to provide an avenue for caregivers to be compensated to stay at home with their loved ones. The stress of working and worrying about your loved one is unbearable which can cause an additional crisis in the home. My husband is only 64 and we never expected this as I'm sure no one else did. I'm crying out for myself as well as other worn caregivers for help to allow us to help our loved ones have the best life possible while fighting this dreadful disease.


M. Ellenbogen  |  01-19-2018

I would like to make you aware of a new trend I am starting to see in the US. This problem that has been created by the opioid crisis. I have now heard of many folks who were receiving pain medications and had dementia are starting to be declined for future pain medications renewal. New folks who need medications are not able to get them. Many people living with dementia are living in pain and are unable to express themselves. This issue has been getting worse and ran into two more families who spoke about this yesterday. Now these folks are suffering even more and this must change quickly. It was always believed to give those with dementia some pain meds to insure they were not living in pain or suffering. Now they are saying that this could lead to more confusion and possible risk of falling. So instead they prefer to cover their ass and deny those folks medications that are needed for comfort in their last few years. Can anything be done.


M. Hogan  |  01-19-2018

Good afternoon. Thank you for the opportunity to once again address the Council. I am a steering committee member of the NTG of which Dr. Janicki is Co-Chair. I wish to follow up on his remarks.

The NTG was formed late in 2010. Our primary goal at the time was to ensure that individuals with ID and their families were included in the National Plan to address AD and other dementias. We have been present at almost all of the meetings since the Council first met, advocating for this vulnerable group of individuals. Some of you at this table have come to expect that we will be present and vocal regarding the needs of those with ID and dementia and their caregivers and/or care partners.

We come to this table quarterly with specific requests for the population we represent. We come to minimize the isolation often experienced by individuals with ID and the continued tendency to offer parallel opportunities that are separate and not always equal.

I believe that it is important that you come to know who we are and recognize the efforts of the NTG outside of this setting. As a small grass roots organization we are focused on increasing support and improving caregiving standards for those with ID, and their families. To this end have done the following:

  • Produced an early detection-screening instrument along with a user manual (NTG-EDSD) that is now available on the NTG website in 13 languages
  • Identified and disseminated Best Practice guidelines and Community Supports guidelines
  • Created a Health practitioner assessment protocol that was published in the Mayo Clinic Proceedings
  • Provided Health Advocacy guidelines, critical for assuring improved medical care
  • Assisted CARF with national program standards for dementia care in rehabilitation facilities
  • Designed a National training curriculum-Dementia Capable Care of Adults with Intellectual Disabilities and Dementia (with Train-the-Trainer component) that has been offered across the US
  • Are partnering with colleagues in Canada on a training curriculum
  • Offer on-going training and webinars for Professionals and Family Members
  • Were instrumental in helping to organize an International Summit on ID and Dementia that was held in Glasgow, Scotland in October of 2016
  • Subsequently published articles in professional journals related to ID and dementia ( from nomenclature to end of life care)
  • Continue to meet with professional organizations to offer technical assistance
  • Explore grant based innovative programs including the exploration of telehealth and tools for dementia assessment with an electronic data storage component
  • Partner with organizations who are recipients of grants from the US Administration on Community Living to insure that their capacity to serve this population increases and standards of care improve
  • Interact with NASDDDS, NASUAD, NACDD regarding state activities
  • Present at National Conferences including the National HCBS Conference to increase awareness of the needs of those with ID and dementia and their family members
  • Represented those with ID and dementia and their caregivers at The National Research Summit on Care, Services, and Supports for Persons with Dementia and Their Caregivers
  • Partner with The Arc, NDSS, Alzheimer's Association on trainings and publications and with NDSS and the National Alliance on Caregiving on the planning of an upcoming Adult Down Syndrome Summit to be held in Arlington, VA in April 2018

And most importantly, for me personally, is the provision of information to families and the hosting of a monthly online family support group for family members from across the US. We are now assisting other organizations that are trying to develop family support options on a more localized level. No caregiver deserves to make this journey in isolation.

As people age and are at increased risk for AD or other dementia, the demands that lie ahead are many and partnerships critical for success. The NTG wishes to reach out and support the efforts of the NAPA Council as you define your next steps. We are hopeful that you will be inclusive of all people in your future plans, that you will make a sincere effort to better understand this special population, that you will take note of our appeals and reflect on what life must be like for those who have faced a lifetime of challenges.

We, in turn, at the NTG can assure you that we will continue to remain dedicated to improving quality of life and quality of care for a population that is often undervalued and underserved and who are very often cared for by a workforce that is undervalued as well. We can and must do better.


M. Janicki  |  01-18-2018

I and Dr. Seth Keller are the co-chairs of the National Task Group on Intellectual Disabilities and Dementia Practices (NTG). The NTG is an affiliate of the American Academy of Developmental Medicine and Dentistry and is associated with the Rehabilitation Research and Training Center on Developmental Disabilities and Health at the University of Illinois at Chicago (

While we were recently discussing the role of the NTG with respect to the Council, it struck us that many Council members may not know why we are here and why we make comments to the Council -- and what are our 'wants'. The NTG was formed in 2010, just before the passage of the National Alzheimer's Plan Act, with a stated mission to advocate for people with intellectual disability affected by dementia and their families and other caregivers. When the NAPA Council came into being, it was opportune for us to have a voice at the national level on behalf of a critical segment of adults affected by Alzheimer's disease and other neurocognitive conditions resulting in dementia.

There are many causes of intellectual disability, some genetic, some due to disease, and some social or environmental. Among the genetic causes, Down syndrome is the one most commonly associated with dementia as adults with Down syndrome are at high risk of Alzheimer's disease and generally manifest early onset dementia. In the United States, it is generally acknowledged that although most persons with an intellectual disability are affected by dementia to the same degree as other adults in the general population, some may be affected earlier and at a greater rate.

The Alzheimer's Association estimates that currently some 5.2 million Americans are affected by dementia, many of whom have Alzheimer's disease. Of these, some 200,000 affected adults are under the age of 65. This includes adults with Down syndrome, many of who are among those 200,000 adults affected with 'early-onset dementia'. Generally, it is believed that about 6% of adults with an intellectual disability will be affected by some form of dementia after the age of 60 (with the percentage increasing with age). For adults with Down syndrome, at least 25% will be affected with dementia after age 40 and at least 50 to 70% will be affected with dementia after age 60. With respect to numbers, it has been projected that there may be at least 54,000 adults with an intellectual disability and mild cognitive impairment (MCI) or dementia in the United States, and that the number of such adults affected by dementia would most likely triple over the coming years.1 Studies have also shown that some 33,000 adults with intellectual and developmental disabilities and dementia are currently living at home with older or other family caregivers. While the number may seem modest with respect to the 5.2 million overall cited by the Alzheimer's Association, these 54,000 comprise a group with high dependencies and a high impact on caregivers, many of whom may have been providing lifelong care. They also represent adults whose needs will have an impact on national long-term care resources as they are Medicaid eligible.

With increased life expectancy and greater numbers of aging people due to the 'baby boom' effect, the number of older at-risk adults will increase significantly over the next twenty years -- as will the prevalence of dementia. The Alzheimer's Association projects that the number of older persons affected by Alzheimer's disease will to about 7.7 million by 2030. This growth also will be mirrored among older adults with an intellectual disability.

There are many similarities in needs between adults with intellectual disability affected by dementia and other adults similarly affected. Both need targeted early detection, diagnostic services, counseling, aid with planning for the future, housing assistance, care management, supports for caregivers, and other special services as dementia progresses.

There are, however, some differences as well. The NTG and other intellectual disability organizations, such as the American Association on Intellectual and Developmental Disabilities, National Down Syndrome Society and The Arc, have noted that

  • After a lifetime of coping with and adapting to a lifelong disability, dementia can have a particularly devastating impact on adults with an intellectual disability as well as on their families, friends, housemates, and services' providers who have been providing key long-term supports and care.
  • Primary care and supports for adults with an intellectual disability affected by dementia can and should be provided within the community and that appropriate services, when available, can preclude inappropriate institutional admissions.
  • State and local developmental disabilities' agencies, the primary resources of specialized services, can help by planning and budgeting for supports of in-community care of adults with an intellectual disability affected by dementia, including help for their family and other caregivers.
  • Specialized assessment and diagnostic resources are effective in identifying dementia among adults with an intellectual disability and their use should be expanded.
  • Knowledge and training in late-life problems, including dementia, of adults with an intellectual disability are often lacking among primary care health providers in community practice and this deficit can be an impediment to early detection and provision of appropriate interventions.
  • Specialized trainings instituted nationally, using workshops, webinars, and other teaching methods, can advance the knowledge and skills among health and social care workers and clinicians working with adults with an intellectual disability affected by dementia.


Now, to the point of why we appear before the Council. We believe that these distinctness areas deserve due consideration by the Advisory Council on Alzheimer's Research, Care, and Services and their remedies warrant inclusion in the National Plan updates -- especially as this group is one of the 'populations disproportionally affected' noted in the original National Plan.2 Further, we ask that the Council recognize that dementia has a particularly devastating impact on people with an intellectual disability and their friends, families and the staff who may be involved with them as advocates and caregivers -- and give this population and its needs due consideration in the Council's deliberations. The National Task Group believes that the federal Council should continue to include -- and expand on -- concerns and considerations for people with intellectual disabilities in its annual updates of the National Plan. To this end, the National Task Group stands ready to assist and contribute to such efforts.


  1. 'My Thinker's Not Working': A National Strategy for Enabling Adults with Intellectual Disabilities Affected by Dementia to Remain in Their Community and Receive Quality Supports. National Task Group on Intellectual Disabilities and Dementia Practice. (2012).
  2. National Plan to Address Alzheimer's Disease. US Department of Health and Human Services. (2012).


S. Hall  |  01-16-2018

I am a care partner and advocate. My husband has frontotemporal degeneration. I am active in the FTD community. This population is often overlooked due to their young age. Programs and services for those with FTD and their care partners are very difficult to find. Most organizations for the aged population do not offer anything for someone under the age of 65.This population is often rejected from memory care facilities due to their age and diagnosis. If they are admitted, they are often asked to leave.

There needs to be a national certification for those working in memory care so they are trained to deal with ALL dementias and ALL symptoms of all dementias. The stress on these younger families is enormous. Many still have young children at home. The cost of their care is twice that of Alzheimer's, which has been shown in a recently published AFTD financial burden study. This leaves younger families financially destitute.

Care partners of those diagnosed at a young age need real respite programs. They often have to work while hiring help at home, as their spouse has left their job and is on SSDI with a 2 year wait for Medicare, so they need to fill that gap of insurance. They work 2 full time jobs, one to keep a roof over their heads and insurance for the family, and one caring for a spouse with dementia.

We are losing too many care partners to stress and onset of stress related diseases at a much younger age. We must all remember that some related dementias are not in an aged population and make programs and services available for this community.


N. Satyadev  |  01-10-2018

I wanted to inform you of two projects my organization is working on that I believe are relevant to the work of this council.

Firstly, our organization was recently approved to launch our low-cost caregiver respite program in partnership with the USC Leonard Davis School of Gerontology. I plan to keep the council informed of developments with this program, but for now more information about our idea can be found here:

Secondly, our organization is leading efforts to pass a California Care Corps Act, building on the framework proposed by Congresswoman Michelle Lujan-Grisham in her National Care Corps Act, which was originally introduced in the 114th Congress and is being reintroduced in the current Congress as a Demo Act. We believe that this legislation is critical to offering care solutions beyond the longstanding IHSS allocations and will help foster an inter-generational culture.

Finally, I want to take a moment to commend the work of Dementia Friendly America as their fast-paced team has been critical to advancing America towards a society in which those diagnosed with dementia feel free to participate in communal activities. Thank you for the time.


C. Johnson  |  01-10-2018

My husband was recently diagnosed with Frontal Temporal Dementia/Degeneration. We have gone from Dr to Dr and realize that few know or have even heard of the horrible disease that is robbing the lives of young men and women. Leaving children to grow without a parent. This disease now falls under the umbrella of Alzheimers but it is not Alzheimers.

I fear there are men and women in our prisons that have this also as it causes the afflicted to behave irrationally. Not only my husband but my now deceased brother, who happened to be one of the largest land owners in California, a highly noted architect was locked up in a horrible county psychiatric hospital because he was walking down the highway and became overly excited trying to explain to the officer he was only going home. You see he also had aphasia that is common with this disease. My brother was transported to hospital and detained on a 5150 in this horrible place until I could get to California and get his attorneys to help me get him out. In fact the hearing officer was very surprised that he had $40 million in cash at his disposal as she thought he was homeless! Homeless with a pair of $1200 Italian loafers on..I'm telling you this because we need to educate Doctors, hospitals, judges and everyone on this disease.


K. Brinkerhoff  |  07-07-2018

I have bvFTD, I don't think that people have an understanding that many with this dementia have a brain that tells them to keep active to walk. Nursing Homes think this means running away. So they lock them down and over medicate them to keep them from leaving. This is destructive to them trying to control a brain that tells them to walk. Instead I say why can't a walking path or the ability to take people with FTD to a walking path not made a part of a clients right. Secondly if no walking path is available have dance classes, walks around the facility or exercise machines such at treadmills or walking machines that can give these people a way to let out that pent up energy the FTD provides you with. Isn't it wonderful there is a dementia that will keep people active and healthy? This is my biggest fear being locked up and medicated in a nursing home and having to hang up my walking shoes because no one will take the time to understand my kind of dementia.

Next I personally believe there are medications out there that can target the part of the brain that is degenerating in the FTD patient. I think continue to look for a cure but if there is a medication that might stimulate that part of the brain or whatever lets find it and make it standard practice for patients with FTD. Maybe its time to find out what kind of medications FTD patients are on and see if some patients are doing better than others and if it might be a medication making the difference. I have seen what many FTD patients are on and it is different from what I am on. So I ask myself is the answer getting a fantastic neurologist over getting the right medication. So lets find a standard if there is one and I believe there is.


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