Performance Improvement 2008. Has the Bench-to Bedside Program Sped Translation of Promising Laboratory Discoveries into New Medical Treatments?


This study assessed the performance of the Bench-to-Bedside (B2B) program, including the breadth of participation, project accomplishments, investigators´ self-reports of programs process and funding, and the benefits of the recent extension of the program to encourage intramural-extramural collaboration. The program encourages innovative projects that involve close collaboration between laboratory and clinical researchers to accelerate patient-oriented research for the diagnosis and therapeutic intervention of medical disorders. Three hundred twenty-four selected investigators were invited to participate in the study by completing a two-part Web-based data-collection instrument.

Over two-thirds of responding project investigators indicated that, in their projects, "collaboration between bench and clinical scientists was enhanced by the project" and that "it would not have been initiated without funds." Nearly 40 percent reported that the program´s "peer review and endorsement" to be helpful. The unstructured responses were nearly all positive endorsements of the B2B program. Three-quarters of the project investigators said they achieved major milestones. For the FY 2006 projects including extramural investigators, 89 percent indicated that new collaborations between intramural and extramural investigators were established as a result of their project and 95 percent of the responding investigators from the latest cohort indicated the intramural/extramural partnership was critical to the success of their projects.

Report Title: A Quantitative Assessment of the NIH Bench-to-Bedside Program: Accomplishments of the First 100 Projects, 1999-2006. Report may be obtained from Federal Contact
Agency Sponsor:
NIH, National Institutes of Health; National Institute of Health Clinical Center
Federal Contact: John I. Gallin, MD, 301-496-4114
Charles Roger Sherman

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"PerformanceImprovement2008.pdf" (pdf, 1.29Mb)

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