Hepatitis A has been one of the most frequently reported vaccine-preventable diseases in the United States. Each year, from 1980 to 1999, there were on average 26,000 cases of acute hepatitis A reported to public health agencies. This corresponds to a rate of approximately 10 cases per 100,000. However, the true number of hepatitis A cases in the United States is believed to be 3-6 times this number. This study developed a detailed report of the model of vaccine prevention including a description of the model, the assumptions of the model, the results of the analysis, a sensitivity analysis, and conclusions. Two manuscripts resulting from this study have been accepted for publication in the journal "Pediatrics." The data from this project were pivotal in the Advisory Committee on Immunization Practices' (ACIP) decision to extend hepatitis A immunization nationwide. ACIP consists of 15 experts in fields associated with immunization who have been selected by the Secretary of the U. S. Department of Health and Human Services to provide advice and guidance on the most effective means to prevent vaccine-preventable diseases.
Report Title: The Cost-Effectiveness of Routine Childhood Vaccination for Hepatitis A in the United States http://aspe.hhs.gov/pic/fullreports/06/8298.htm
Agency Sponsor: CDC-OD-OSI, Office of the Director, Office of Strategy Innovation
Federal Contact: Slaton, Terrie, 404-639-7647
Performer: Research Triangle Institute; Research Triangle Park, NC
PIC ID: 8298