This report examined obstacles to designing a uniform data set (UDS) to assess the impact of activities funded by the Office of Minority Health (OMH), which administers a broad array of grants and contracts aimed at eliminating disparities in health outcomes and access to services for minority groups. Taking into account the obstacles, as well as guidelines, legislation, performance measurement methodology, and databases, the evaluators described a recommended data system. The literature review attended to a variety of important contextual issues (e.g., recommendations regarding the evaluation of programs like those administered by OMH). Site visits and focus groups with relevant players were carried out, and the UDS was then pilot-tested over a 3-month period with nine OMH grantees. In addition, a Technology Survey was conducted by telephone with 22 participants to assess the capacity and preference for gathering data for the UDS. Based on analyses summarized in the report, the evaluators recommended a web-based database and report generating system that would be user-friendly. In addition, it would allow the various projects around the country to enter their data into a national system, obtain needed technical support, and generate reports of data that were useful locally.