Overview and Inventory of HHS Efforts to Assist Incarcerated and Reentering Individuals and their Families . Medications Development for Incarcerated Individuals and Parolees


Type of Activity: Research

Funding Mechanism: Grants

Total Available Funding: N/A

Number of Awards: 9

Average Award Amount (current year): $360,000

Length of Project Period: Varies

Federal Partners: N/A

Summary: These projects are testing treatments for opiate addiction and its medical consequences within criminal justice settings. Specifically, studies will be evaluating the effectiveness of initiating opiate replacement therapy (methadone) prior to release from prison vs referral to a methadone-treatment program on release, on reducing HIV risk behaviors; testing the efficacy of buprenorphine as well as methadone, prior to release from incarceration; testing a long-acting form of the opiate antagonist naltrexone; and adapting and testing a continuity of care model between the prison and community settings for inmates infected with Hepatitis C virus who have a history of drug use and comorbid psychiatric disorders.

Background: There are currently two medications available for opiate addiction, methadone and buprenorphine. However, these have not been widely adopted by criminal justice systems. Research to demonstrate their effectiveness within criminal justice populations as well as the development and testing of additional medications for both drug abuse as well as its medical consequences (e.g., HIV, Hepatits C) is necessary to encourage the implementation of these treatments within the criminal justice system.

Principle Investigator Location Title
Current Grantees: 
Josiah Rich Miriam Hospital
Providence, RI
Opiate Replacement Therapy at Release from Incarceration
Charles O’Brien University of Pennsylvania 
Philadelphia, PA
Treatment Study Using Depot Naltrexone (1/6) Philadelphia Coordinator/Data Management Site
Peter Friedmann Rhode Island Hospital 
Providence, RI
Treatment Study Using Depot Naltrexone (2/6) Rhode Island Protocol Treatment Site
Joshua Lee NYU School of Medicine 
New York, NY
Treatment Study Using Depot Naltrexone (3/6) Bellevue Protocol Treatment Site
Edward Nunes Columbia University 
New York, NY
Treatment Study Using Depot Naltrexone (4/6) Columbia Protocol Treatment Site
Timothy Kinlock Friends Research Institute 
Baltimore, MD
Treatment Study Using Depot Naltrexone (5/6) Baltimore Protocol Treatment Site
Peter Friedmann Rhode Island Hospital 
Providence, RI
Stabilize Addiction/Affect, Begin Inmates’ Interferon for HCV of Liver (STAABIHL)
Curt Beckwith Miriam Hospital
Providence, RI
Comprehensive HIV Strategies for Jails
Timothy Flanigan Miriam Hospital
Providence, RI
HIV and Other Infectious Consequences of Substance Abuse

 Evaluation Activities: Peer-reviewed publications to disseminate scientific data and findings; presentations of findings at scientific meetings.

Future Prospects: Future prospects dependent upon receiving highly meritorious investigator-initiated projects and funds available.


Susan Weiss, Ph.D.
Phone: (301) 443-6071
Email: susan.weiss@nih.gov

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