National Plan to Address Alzheimer's Disease: 2018 Update. Strategy 1.E: Facilitate Translation of Findings into Medical Practice and Public Health Programs

10/19/2018

Currently, promising research and interventions are published in the research literature and presented at scientific meetings. Additional steps are needed to highlight promising findings and to facilitate dissemination and implementation of effective interventions to the general public, medical practitioners, the pharmaceutical industry, and public health systems, quickly and accurately.

(UPDATED) Action 1.E.1: Leverage public and private collaborations to facilitate dissemination, translation, and implementation of research findings

NIA continues to expand its efforts to educate clinicians about recent research findings; clinical practice tools for assessment, diagnosis and management of cognitive impairment; training materials; a patient checklist handout in English and Spanish, and other resources, which are available online in a mini-portal of resources for professionals.

For more information, see:

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(UPDATED) Action 1.E.2: Continue to promote use of the Alzheimer's Disease Education and Referral Center to provide evidence-based information on Alzheimer's disease and related dementias to the public and others

NIA's ADEAR Center routinely disseminates information on AD/ADRD research findings through the NIA website, regular weekly and monthly email alerts to more than 50,000 subscribers, and social media (Twitter and Facebook). Progress in AD/ADRD research is also reported in the annual NIH Bypass Budget proposal.

For more information, see:

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(ONGOING) Action 1.E.3: Issue guidance about drugs for early-stage Alzheimer's disease and related dementias

In February 2013, the FDA published a Draft Guidance for Industry: Alzheimer's disease: Developing Drugs for the Treatment of Early Stage Disease which discusses the Administration's current views on how trials in subjects with pre-dementia AD might be designed, conducted, and analyzed. The document also discusses a potential accelerated regulatory pathway for patients with the earliest stages of the disease. FDA published a final version of that guidance in 2014 that reflects feedback received from industry, academia, advocacy groups, physicians, and patients/caregivers.

In 2013, FDA endorsed a disease-modeling tool submitted by the Coalition Against Major Diseases for trials in mild-to-moderate AD that will enable sponsors to design more efficient trials in these populations.

In 2018-2019, FDA will continue to work with outside consortia to attempt to formally qualify (via the Drug Development Tool Qualification Process) both novel clinical endpoints as well as biomarkers for trial enrichment for use in AD trials.

For more information, see:

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(UPDATED) Action 1.E.4: Expand and disseminate research on co-occurring conditions and dementias

In January 2016, CDC released the Progress Report of public health Road Map action item accomplishment and next steps. In 2017, the development process of the third Road Map began that will identify action items for public health professionals related to cognitive health through 2023. The third Road Map will be released in late 2018.

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(UPDATED) Action 1.E.5: Provide information to the public on brain health

On February 2, 2016, NINDS launched a public health campaign on the link between hypertension and cognitive decline for integration with the HHS Million Hearts Campaign. This campaign is still active.

The Brain Health Resource, a presentation toolkit on brain health as we age, was developed by ACL with scientific review by NIH and CDC for use at senior centers and in other community settings and was updated in 2018. Written in plain language, the evidence-based resource explains what people can do to help keep their brains functioning best. In 2016, the toolkit was expanded to include materials in Spanish and a new brain health module entitled "Medicine, Age, and your Brain".

Additionally, the campaign, "What is Brain Health?" formerly managed by ACL was transferred to NIA in 2017. NIA also maintains a web portal on Cognitive Health and Older Adults.

For more information see:

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(NEW) Action 1.E.6: Leverage public and private collaborations to facilitate dissemination, translation, and implementation of research findings

CDC is working with the American College of Preventive Medicine. A Curriculum is being developed to increase physician and health care professionals' awareness of brain health as a serious health condition and to increase the number of physicians and health care professionals acting to address, diagnose, and refer patients with brain health issues to care and community support programs. The module will be included as an elective in the Lifestyle Medicine Core Competencies Online Program.

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(NEW) Action 1.E.7: Facilitate translation of findings into public health practice

CDC has provided funds to the Alzheimer's Association to co-develop the third in a series of Healthy Brain Initiative (HBI) Road Maps to advance cognitive health as an integral component of public health. This "Healthy Brain Initiative State and Local Public Health Partnerships to Address Dementia, The 2018-2023 Road Map" project, outlines how state and local public health agencies and their partners can continue to promote cognitive health, address cognitive impairment for people living in the community, and help meet the needs of caregivers. Twenty-five specific actions are proposed in four traditional domains of public health: educate and empower, develop policies and mobilize partnerships, assure a competent workforce, and monitor and evaluate.

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