An Inventory Of Federally Sponsored HIV And HIV-Relevant Databases. Database: Women and Infants Transmission Study (WITS)


NIAID, in collaboration with NICHD and NIDA

Purpose Of The Database And Study Design: WITS is a multi-site collaborative longitudinal study of US HIV positive women and their offspring. Inner-city women, children, and drug users are the particular focus of WITS and WITS II. Almost one-half (45 percent) of WITS/WITS II subjects are African-American and 37 percent are Hispanic. Study sites include: Brigham and Children’s Hospital, University of Illinois at Chicago, Columbia University, the State University of New York (SUNY) Brooklyn, and Baylor University in Houston. Enrollment sites include Chicago, Boston, New York City, and San Juan. Enrollment was initiated in 1989 to determine risk factors for perinatal transmission and disease progression. This initiative supports longitudinal clinical, virologic, and immunologic evaluations, as well as an extensive repository of maternal and infant blood specimens. WITS currently focuses on several critical topics in perinatal HIV research including: factors contributing to perinatal HIV transmission, pathogenic aspects of primary HIV infections in infants, early immunologic and viral markers of rapid versus more stable disease progression, role of maternal drug use on transmission risk and disease progression, and assessment of evidence for or against potential immune response to HIV exposure among uninfected infants, as well as the effects of perinatal exposure to antiretrovirals.

Nature Of The Data Collected: Data collection has been conducted in two phases. In the first phase (1990 to 1993), three cohorts were enrolled: HIV positive pregnant women, their infants, and HIV positive non-pregnant women. In the second phase (1983 to present), HIV positive pregnant women and their infants were enrolled.

Unit Of Analysis: Longitudinal collection of clinical specimen, physical examination, and interview data

Data Collection Methods: Not available

General Attributes: About 1,800 pregnant women and 1,400 infants have enrolled.

Major Data Constructs And Key Data Elements: Adult specimens include blood and genital samples. Laboratory specimens are obtained from subjects at specified times throughout the study period. The content and timing of the laboratory testing varies depending upon the subject’s status (i.e., whether a woman or a child), the mother’s pregnancy status, and gestation at the time of enrollment.

Strengths And Weaknesses Of The Study Design And Database: None identified

Gaps In The Data Collected And Factors Leading To The Gaps: None identified

Feasibility Of Linking With Other Databases: No information provided

Process To Access The Database And Contact Person:

Selected Citations:

Hanson IC, Antonelli TA, Sperling RS, Oleske JM, et al. Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine. Journal of AIDS and Human Retrovirology. 20(5): 463-367, 1999.

Rich KC, Siegal JN, Leurgans SE, Landay AL. Induced beta-chemokine and cytokine response in pregnant HIV-1 infected women and risk of perinatal transmission. International Conference on AIDS. 12: 397 (Abstract No. 23279), 1998.

Pacheco-Acosta E, Antonella T, Higgins A, Moroso NG, et al. Reproductive choices in the Women and Infant Transmission Study (WITS): pre and post ACTG 076 results. International Conference on AIDS. 12: 198 (Abstract No. 13565), 1998.

McIntosh K, FitzGerald G, Pitt J, Bremer JW, et al. A comparison of peripheral blood coculture versus 18- or 24-month serology in the diagnosis of human immunodeficiency virus infection in the offspring of infected women: Women and Infants Transmission Study. Journal of Infectious Disease. 178(2): 560-563, 1998.

Kalish LA, Diaz C, Rick KC, Shearer WT, et al. Virologic, immunologic, and clinical indicators of disease progression in a perinatal HIV cohort: the Women and Infants Transmission Study (WITS). International Conference on AIDS. 12: 160 (Abstract No. 13368), 1998.

Diaz C, Hanson C, Cooper ER, Read JS, et al. Disease progression in a cohort of infants with vertically acquired HIV infection observed from birth: the Women and Infant Transmission Study (WITS). Journal of AIDS and Human Retrovirology. 18(3): 221-228, 1998.

Cowles MK, Palumbo P, Virus detection, virus load, and disease progression in perinatally infected infants. . International Conference on AIDS. 12: 160-161 (Abstract No. 13369), 1998.

Kalish LA, Pitt J, Lew J, et al. Defining the time of fetal or perinatal acquisition of human immunodeficiency virus type 1 infection on the basis of age at first positive culture: Women and Infant Transmission Study (WITS). Journal of Infectious Disease. 175(3): 712-175, 1997.

Pitt J, Henrard D, Fitzgerald G, Lew J. et al. Association of HIV-1 antibodies (Ab) and ICD p24 antigen (Ag) with perinatal HIV-1 transmission. Conference on Retroviruses and Opportunistic Infections. 158 (Abstract No. 505), 1997.

Hanson IC, Pitt J, McIntosh K, Sherrieb K, et al. Standardized assessment of infants with indeterminate (IND) HIV-infection status followed in the Women and Infants Transmission Study (WITS). International Conference on AIDS. 11(2): 87 (Abstract No. We.B.3176), 1996.

Cooper ER, Hanson C, Diaz C, Abboud R, et al. Encephalopathy and HIV disease progression in a cohort of children with perinatally acquired HIV infection: the Women and Infants Transmission Study (WITS). International Conference on AIDS. 11(2): 26 (Abstract No. We.B.313), 1996.

Brambilla D, Leung S, Lew J, Shapiro D, et al. Interkit differences in plasma HIV-1 RNA levels in mothers enrolled in WITS/ACTG 076.Conference on Retroviruses and Opportunistic Infections. 178 (Abstract No. 616), 1997.