An Inventory Of Federally Sponsored HIV And HIV-Relevant Databases. Database: Women’s Interagency HIV Study (WIHS)

07/01/2000

NIAID, in collaboration with National Institute on Drug Abuse (NIDA), National Cancer Institute (NCI), National Institute on Dental Research and the CDC

Purpose Of The Database And Study Design: The WIHS is a multi-center, prospective study established in 1993 to carry out comprehensive investigations of the impact of HIV disease in women. WIHS was established in 1993 in tandem with a similar study, the HIV Epidemiology Research Study (HERS) coordinated by the CDC. The six WIHS sites are organized as a consortium. The sites are located in New York (two sites), the District of Columbia, Chicago, San Francisco, and Los Angeles. NIAID, NICHD, NIDA, NCI, and NIDR support various components of WIHS.

Nature Of The Data Collected: Longitudinal collection of physical examination, clinical specimen, and interview data

Unit Of Analysis: Study subjects are followed longitudinally

Data Collection Methods: Study subjects were recruited from HIV primary care clinics, hospital-based programs, and a variety of other community-based programs. To participate in WIHS, women must have been at least 13 years of age, provide informed consent to participate, be tested for HIV, complete an interview, participate in a baseline visit, and provide blood for laboratory testing. Study subjects participate in a baseline visit and follow-up visits every six months conducted by interviewers and examiners trained centrally. The baseline visit includes a physician and gynecological examination, oral examination, tuberculin and anergy skin testing, and laboratory specimen collection. Their medical records are also abstracted for all hospitalizations and HIV-related conditions.

General Attributes: A total of 2,641 women (2,066 HIV positive and 575 seronegative women) are under follow-up.

Major Data Constructs And Key Data Elements: The baseline visit interview gathers data regarding: demographic characteristics, medical and health history, obstetric and gynecologic history, drug use, sexual behavior, health care use, and psychosocial measures including quality of life. A baseline medical and gynecologic examination is conducted also. Similar data are collected at six-month intervals.

Strengths And Weaknesses Of The Study Design And Database: The generalizability of the groups studied is unclear.

Gaps In The Data Collected And Factors Leading To The Gaps: None identified

Feasibility Of Linking With Other Databases: Feasibility is unclear

Process To Access The Database And Contact Person:

Selected Citations:

Cejtin HE, Komaroff E, Massad LS, Korn A, et al. Adherence to colposcopy among women with HIV infection. JAIDS. 22(3): 247-252, 1999.

Weber K, Cohen M, Riester K, Holman S, et al. HIV research and women: what influences attrition? International Conference on AIDS. 12: 813 (Abstract No. 42202), 1998.

Ohmit S, Schuman P, Schoebbaum E, Rompaolo A, et al. Adherence to antiretroviral therapy (ART) among women in the HIV Epidemiology Research Study (HERS) and Women’s Inter-Agency HIV Study (WIHS). International Conference on AIDS. 12: 590 (Abstract No. 32347), 1998.

Levine AM, Melnick SL, Preston-Martin S, Silver S, et al. Use of mammography screening by HIV infected women: Women’s Interagency HIV Study (WIHS). International Conference on AIDS. 12: 590 (Abstract No. 32347), 1998.

Kovacs A, Chan L, Bremer J, Meyer WA, et al. Impact of plasma RNA on CD4 change and outcome for women in the Women’s Interagency HIV Study. International Conference on AIDS. 12: 803 (Abstract No. 42153), 1998.

Currier J, Richardson J, Masari L, Levine AM. Prevalence and determinants of non-use of antiretroviral therapy among women: Women’s Interagency HIV Study (WIHS). International Conference on AIDS. 12: 831 (Abstract No. 42288), 1998.