An Inventory Of Federally Sponsored HIV And HIV-Relevant Databases. Database: HIV Outpatient Study (HOPS)


Purpose Of The Database And Study Design: To collect information about the demographic characteristics, symptoms, OIs, treatments, and laboratory values of a dynamic cohort of ambulatory HIV positive patients seen at eight to twelve clinics nationwide. The main objective of the project is to assess the efficacy, durability, and adverse effects of antiretroviral therapy in clinical practice.

Nature Of The Data Collected: Longitudinal medical record reviews conducted to study a natural cohort of HIV positive adults

Unit Of Analysis: Individual patients treated at predominantly hospital-based outpatient clinics

Data Collection Methods: Beginning in 1993, medical records at eight to twelve hospital-based HIV clinics are reviewed on an ongoing basis. Medical records are abstracted using a standardized abstraction tool, and the data are automated.

General Attributes: From 1993 to 1999, about 5,000 HIV positive patients were seen during approximately 70,000 visits to their HIV clinicians

Major Data Constructs And Key Data Elements: Demographic characteristics, source of payment, HIV risk group, tobacco and alcohol use, symptoms at the time of the visit, definitive and presumptive disease and conditions presented at the visit, and complete therapeutic drug histories (including start and stop dates and dosage).

Strengths And Weaknesses Of The Study Design And Database: The cohort is treated at a small number of sites and thus may not be generalizable to the larger HIV positive population. Patients may be treated at other sites during intervening periods. Data from those other treatment episodes are not collected.

Gaps In The Data Collected And Factors Leading To The Gaps: HOPS is a convenience sample.

Feasibility Of Linking With Other Databases: Not available.

Process To Access The Database And Contact Person: For more information contact: Chief, Surveillance Branch, Division of HIV/AIDS Prevention, Surveillance, and Epidemiology, CDC, Mailstop E-47, 1600 Clifton Road, NE, Atlanta GA 30333; (404) 639-2050.

Selected Citations:

Moorman AC, Holmberg SD, Marlowe SI, et al. Changing conditions and therapies of ambulatory HIV positive patients: the HIV Outpatient Study (HOPS). Annuals of Epidemiology. 9(6) 349-357, 1999.

Von Bargen JC, Moorman AC, Holmberg SD. How many pills do patients with HIV infection take? (letter) JAMA 280(1): 29, 1998.

Moorman AC, Von Bargen JC, Palella FJ, Holmberg SD. Pneumocystis carinii pneumonia incidence and chemoprophylaxis failure in an ambulatory HIV positive population. Journal of AIDS and Human Retrovirology. 19(2): 182-188, 1998.

Smith D. The HIV Epidemiology Research Study, HIV Outpatient Study, and the Spectrum of Disease Studies. Journal of AIDS and Human Retrovirology. 17(Supple. 1): S17-S19, 1998.

Palella FR, Delaney KM, Moorman AC, et al. Declining mortality and morbidity in HIV positive ambulatory patients. NEJM. 17:253-261, 1998.

Holmberg SD, Moorman AC, Von Bargen JS, et al. Possible effectiveness of clarithromycin and rifabutin for Cryptosporidiosiumchemoprophylaxis in HIV positive patients. JAMA. 279:384-386, 1998.

Moorman A, Von Bargen J, Palella F, Holmberg S. Determinants of “breakthrough” Pneumocystis carinii pneumonia (PCP) in the HIV Outpatient Study (HOPS). Conference on Retroviruses and Opportunistic Infections. 118 (Abstract No. 294), 1997.

Loveless M, Delaney K, Moorman A, McCabe r. Quantification of pain syndromes in the HIV Outpatient Study (HOPS). Conference on Retroviruses and Opportunistic Infections. 128 (Abstract No. 350), 1997.

Fisher D, Fuhrer J, Moorman A, Pathak D. Resource utilization in HIV patients diagnoses with CMV. Conference on Retroviruses and Opportunistic Infections. 121 (Abstract No. 307), 1997.

Ward DJ, Fisher DJ, Holmberg SD, Delaney K, et al. Experience with MAC prophylaxis in the HIV Outpatient Study (HOPS). Conference on Retroviruses and Opportunistic Infections. 85, 1996.

Moorman AC, Holmberg SD, Fuhrer J, Loveless M, et al. The HIV Outpatient Study (HOPS): description and initial findings. International Conference on AIDS. 11(2):100 (Abstract No. We.B.3253, 1996.

Moorman AC, Ward DJ, Brown KM, Fisher DJ, et al. Differential antiretroviral use in the HIV Outpatient Study (HOPS). National Conference on Human Retroviruses and Related Infections. 105, 1995.