The Department of Health and Human Services (HHS) is one of the largest federal departments, the nation's largest health insurer, and the largest grant-making agency in the United States federal government. The Department promotes and protects the health and well-being of all Americans and provides world leadership in biomedical and public health sciences. HHS accomplishes these objectives through an array of programs in basic and applied science, public health, income support, child development, and the financing and regulation of health and social services. The Department manages this broad range of activities in collaboration with its state, local, tribal, and non-governmental partners, and with the coordination of the staff agencies in the Office of the Secretary. Appendix I provides a brief description of HHS Agencies and staff offices.