Examination of Clinical Trial Costs and Barriers for Drug Development. E.3.3 Difficulties in Recruiting and Retaining Participants


  • Patient recruitment requires a substantial investment of time and money.
  • Failure to recruit can cause costly delays or trial cancellation, wasting resources.
  • There is competition for limited patient pools for certain conditions, such as rare cancers and multiple sclerosis.
  • Clinical trial sites are often selected based on the location of investigators rather than patients.
  • Knowledge, attitudes, and incentives of potential participants and their physicians hinder participation.


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