In Kentucky, New Jersey, and Philadelphia we examined a number of subgroups of families to determine whether we could detect differences between experimental and control groups on placement and substantiated allegations subsequent to random assignment within each subgroup. Most of the subgroups were defined in terms of problems of the family, for example, substance abuse, financial difficulties, and depression. The number of cases in Tennessee was not sufficient to support subgroup analysis. No subgroups were found in which there were positive effects of family preservation services on placement or subsequent maltreatment. Hence, the effort to find subgroups for which family preservation service was successful in reducing placement was not successful.