Dissemination and Adoption of Comparative Effectiveness Research Findings When Findings Challenge Current Practices. Study Results

01/01/2013

Table 6.1 presents the key results from the CPOE study. Between pre and post periods in the same hospital units, unintercepted serious medication errors decreased from 10.7 events per 1,000 patient-days to 4.86 events per 1,000 patient-days—a reduction of 55 percent—and unintercepted potential ADEs declined 84 percent, from 5.99 per 1,000 patient-days to 0.98 per 1,000 patient-days. The analysis indicated that the team intervention had no incremental benefit over the implementation of CPOE alone (hence the pooling of the intervention arms and the analysis as a pre-intervention/post-intervention study). These results suggested that other hospitals should consider CPOE adoption the principal quality improvement intervention to reduce unintercepted serious medication errors.

Table 6.1

Results of the CPOE Study

Outcome

Pre Rate (events/1,000 patient-days, mean)

Post Rate (events/1,000 patient-days, mean)

Difference (%)

p-value

Unintercepted serious medication errorsa

10.70

4.86

–55

0.01

Preventable ADEs

4.69

3.88

–17

0.37

Unintercepted potential ADEs

5.99

0.98

–84

0.002

All ADEs

16.00

15.20

–5

0.77

Unpreventable ADEs

11.30

11.30

0

0.99

All potential ADEs

11.70

3.38

–71

0.02

Intercepted potential ADEs

5.67

2.40

–58

0.15

aPrimary outcome.

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