The remainder of this report is organized as follows. Chapters Two through Six summarize the five case studies. Each chapter includes a brief description of the clinical-practice context leading up to the CER findings and a summary of key results, along with a summary of the key barriers to and enablers of the CER translation process. Chapter Seven presents a summary of themes that emerged consistently, organized around five root causes of failure of CER to change clinical practice, along with an assessment of the study’s limitations. Chapter Eight discusses the policy implications of our findings and suggests opportunities for future research.