Dissemination and Adoption of Comparative Effectiveness Research Findings When Findings Challenge Current Practices. New Evidence Following Initial Release of CATIE Results

01/01/2013

Additional results from CATIE and similar trials have consistently supported CATIE’s initial findings. Findings from quality-of-life and neurocognitive substudies showed only marginal improvements across treatment groups, with no significant differences between groups. In 2006, a cost-effectiveness analysis using CATIE data found that the additional cost of atypical antipsychotics was not justified given the similar effectiveness of the first- and second-generation treatments. A second trial that compared the effectiveness of first- and second-generation medications in the United Kingdom, the CUTLASS trial, was released in 2006 and confirmed the results of CATIE across most outcomes. A paper released in 2010 showed that the incidence of tardive dyskinesia has remained relatively constant since the 1980s, despite the widespread shift to second-generation medications (Woods, Morgenstern, et al., 2010). These findings reinforce the conclusion that the initial concerns about the extrapyramidal side effects of first-generation medications were overblown.

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