Dissemination and Adoption of Comparative Effectiveness Research Findings When Findings Challenge Current Practices. The Comparative-Effectiveness Question


Despite the lower rate of extrapyramidal symptoms of second-generation antipsychotics, the optimal choice of drug treatments for patients with schizophrenia had been disputed for at least four reasons: (1) uncertainties surrounding effectiveness in controlling psychotic symptoms; (2) uncertainty about the relative incidence of side effects, including tardive dyskinesia and metabolic side effects; (3) some evidence that second-generation antipsychotics improve cognition; and (4) the high cost of the medications. These concerns drove a need to assess the overall value of second-generation antipsychotics.

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