By: Eric C. Schneider, Justin W. Timbie, D. Steven Fox, Kristin R. Van Busum, John P. Caloyeras
This report summarizes findings from a qualitative analysis of the factors that impede the translation of comparative effectiveness research (CER) into clinical practice and those that facilitate it. A case study methodology is used to explore the extent to which these factors led to changes in clinical practice following five recent key CER studies. The enabling factors and barriers to translation for each study are discussed, the root causes for the failure of translation common to the studies are synthesized, and policy options that may optimize the impact of future CER are proposed. This report should be of interest to policymakers, including those in both federal agencies and nongovernmental entities involved with the generation or translation of CER research, as well as to public and private purchasers, clinicians, decision support companies, and patient-advocacy organizations.