Analytical Framework for Examining the Value of Antibacterial Products. Ciai


Total Number of Cases that Result in Death

Using the Compressed Mortality File, we estimated the number of deaths attributable to CIAI to be 14,136 in 2008, or 4.65 per 100,000 population.  Applying this rate to 2011 population estimates yields a total of 14,554 deaths attributed to CIAI in 2011.

QALYs Lost

Using data available in the Compressed Mortality File and NSVR, we estimated the total number of deaths by age group for the year 2011.  To illustrate the calculation, there were an estimated 3,982 deaths caused by a CIAI among Americans aged 75-84 in 2011.  The life expectancy for an 80 year old is 8.8 years; therefore, total QALYs lost by the 75-84 age cohort is 35,042 (8.8 × 3,982).  Summing lost QALYs across all ages yielded a total of 243,987 QALYs lost due to CIAI deaths in 2011.

Mortality Cost

To calculate VSL-based mortality costs, we multiplied the number of deaths in each age group by the VSL for that age group.  For CIAI, this resulted in $31.6 billion in mortality costs.  The average per-patient VSL, weighted by the number of deaths by age, is $5.59 million.

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