This research brief highlights interim findings from the evaluation of ¡Cuídate!, an HIV/AIDS prevention program that uses an approach culturally tailored to Latino youth. The study examined data from three different replications of ¡Cuídate!, pooling the data to examine the overall program impact. These findings are based on a short-term follow-up survey administered to study participants six months after they enrolled in the study. Early findings suggest that ¡Cuídate! was effective in increasing knowledge about sexual risk behavior, producing more positive attitudes toward avoiding risk and increasing negotiation skills. However, after six months, there was no difference between youth who participated in ¡Cuídate! and those who didn’t in the level of sexual risk behaviors reported. These are interim findings; a final assessment of the program’s effectiveness will come from the findings of the longer-term follow-up survey at 18 months.