Market Barriers to the Development of Pharmacotherapies for the Treatment of Cocaine Abuse and Addiction: Final Report. Case Studies: LAAM, Naltrexone, Clozapine, and Nicorette
The purpose of the case studies is to gain insight into the experiences of companies that are relevant to developing and marketing medications for drug abuse and addiction. Presented below are two in-depth case studies of LAAM (Roxanne), for heroin addiction, and naltrexone (DuPont Merck), for heroin (as Trexan) and alcohol (as ReVia) addiction. I
Market Barriers to the Development of Pharmacotherapies for the Treatment of Cocaine Abuse and Addiction: Final Report. Scenario 5: Second Indication
Company S has a smoking cessation medication, Product S, that was recently introduced to the market. In its first two years, Product S has been highly successful, with projected PAR exceeding $500 million. Company researchers also have found strong early evidence that Product S may be very effective as a medication for cocaine addiction, and are e
Market Barriers to the Development of Pharmacotherapies for the Treatment of Cocaine Abuse and Addiction: Final Report. Scenario 4: Vaccine
In Scenario 4, the government has conducted preclinical R&D on a highly promising Product V that is designed to work as a vaccine with an annual booster.
Market Barriers to the Development of Pharmacotherapies for the Treatment of Cocaine Abuse and Addiction: Final Report. Scenario 2: Biotech Gets Help
In this scenario, a small biotechnology firm, Company B, takes on the full product development cycle with a new class of compounds based on a recent scientific breakthrough that is highly specific to cocaine receptor neuropharmacology. The company anticipates that a new Product B from this class of compounds will have excellent compliance in the u
Market Barriers to the Development of Pharmacotherapies for the Treatment of Cocaine Abuse and Addiction: Final Report. Scenarios of Company Decision Making
This report presents several scenarios of pharmaceutical company decision making regarding undertaking projects to develop pharmacotherapies for substance abuse (e.g., cocaine) under various sets of market conditions. Using a quantitative model developed by The Lewin Group, the market conditions are translated into financial and other parameters t
Market Barriers to the Development of Pharmacotherapies for the Treatment of Cocaine Abuse and Addiction: Final Report. Internal Rate of Return and Reducing the Time to Market
Another important investment criterion used by some companies is the internal rate of return (IRR). The IRR is the rate of interest at which the present value of all net cash flows into and out of a project over a specified time interval equals zero. A higher IRR makes an investment opportunity more favorable.
HHS Strategic Goals and Objectives - FY 2001 . Objective 2.5 - Increase the Proportion of Older Americans Who Stay Active and Healthy
How We Will Accomplish Our Objective We will support an initiative to prevent falls--a leading cause of functional decline in the elderly. Our strategy will focus on:
While almost all health insurance policies cover the usual medical expenses associated with hospital, surgical and out-patient care received from licensed facilities and medical personnel, other requirements for coverage can be implemented through state regulations. One way to spread the cost of a medical condition or treatment among a broad pop
ABA (American Bar Association). 1983. Board and Care Report: An Analysis of State Laws and Programs Serving Elderly Persons and Disabled Adults . Report to the Department of Health and Human Services. Washington, DC. Avorn, J., P. Dreyer, K. Connely, and S.B. Soumerai. 1989. Use of psychoactive medication and the quality of care in rest homes.
A Description of Board and Care Facilities, Operators, and Residents. 6.4 Cognitive and Functional Status
6.4.1 Cognitive Impairment In the early 1980s, Dittmar and Smith (1983) found 30 percent of the residents were “confused,” while Sherwood and colleagues (1981) found 24 percent were cognitively impaired ( Exhibit 6-4 ). A prevalence rate of 40 percent with moderate to severe cognitive impairment in this study indicates a significant increase
Disability levels in the area of psychiatric conditions, other than Alzheimer’s and other dementias, were about the same as in the 1980s, with one-third of the residents in the DRI study, as in this study, reporting a mental, emotional, or nervous condition. Similarly, as shown in Exhibit 6-4 , the percentage of residents with a diagnosis of me
5.5.1 Direct Care Operators Almost half of the direct care operators of board and care homes (49 percent) earned between $15,000 and $49,999 annually; 26 percent earned less than $15,000, and 25 percent earned $50,000 or more annually. There were no significant differences between operator salary levels by facility licensure status.
Only half of the staff members in board and care homes who gave shots were LVNs or LPNs, and another one-fifth were RNs. Over one-fourth of the staff members in board and care homes who gave shots were not licensed nurses (28 percent). The vast majority of staff members who gave shots (86 percent) had training in caring for the elderly, mentally i
State Nursing Home Quality Improvement Programs: Site Visit and Synthesis Report. Quality Monitoring Program
The Quality Monitoring program was mandated by SB 1839 that was passed in 2001. The program was implemented in April 2002, and had been in operation for only a few months at the time of our site visit to the state in August 2002.
State Nursing Home Quality Improvement Programs: Site Visit and Synthesis Report. Statewide Quality Review 
The Statewide Quality Review provides an independent, structured assessment of the appropriateness of care for specific clinical issues identified by the state as quality improvement priorities. This initiative is a legislatively-mandated annual study of quality of care, quality of life, and consumer satisfaction in Texas nursing homes. First cond
State Nursing Home Quality Improvement Programs: Site Visit and Synthesis Report. Impact of Missouri's Quality Improvement Programs on Quality of Care/Quality of Life
Missouri is far ahead of other states in terms of evaluating the impact of its quality improvement programs. Dr. Rantz uses MDS data to measure the change in quality indicators associated with the program and has published several journal articles that report these results. In addition, facilities that receive QIPMO visits provide feedback through
State Nursing Home Quality Improvement Programs: Site Visit and Synthesis Report. Quality Assurance Plan (COMAR 10.07.02.46)
The QA plan must include procedures for concurrent review of resident status, ongoing monitoring of resident status, handling and reporting of patient complaints, procedures for accidents and incidents, and procedures for implementing abuse and neglect regulations (e.g., family notification).
Long-Term and Post-Acute Care Providers Engaged in Health Information Exchange: Final Report. Appendix M. Glossary
Accountable Care Organization (ACO)